I'd have to recommend The Ovalon in Hazleton for Italian food. It's been around for years and is the place where people used to meet and discuss business back in the 60s and 70s.
Scattons is a curious mix of phenomenal food and odd decor. I haven't been there in a couple years. The food was awesome every time.
The Alberdeen is a beautiful restaurant in Mountain Top. I like the charbroiled combination platter- a lamb chop, a pork chop, and a petit filet. Mmmmmm. Gotta get that daily ration of animal fats!
We ate last week at The Top of the 80s, located at the Hampton Inn at the junction of I-80 and I-81. The dining room has a magnificent view of the Conyngham Valley. We could see Christmas lights for miles. The restaurant has moved upscale in the last few years; in keeping with the personality of the area, it's not very adventurous but it is very good.
Portions in NEPA are huge, too big really; prices are what Philadelphians and New Yorkers would call ridiculously low. Menus are conservative. NEPA diners expect no surprises, and they expect good quality.