For bar-hopping downtown after work I like Ferry Plaza and the bar at Jeanty @ Jack's. Palio d'Asti if I'm in the mood for Italian, B44 for cava.
Slanted Door would be great if you could get a seat. Rubicon is incredible if you want to split a bottle but the by-the-glass list is relatively disappointing. I don't think so much of London Wine Bar. I want to like Vino Venue but I don't think the gas system keeps the wine all that well. Lulu's little bar in the side room is nice but that's quite a schlep.
What else is good for wine nuts downtown? So many restaurants with good wine lists, I'm sure there are more places I should learn about.