There are so many terrific out of the way Italian restaurants in Toronto, why limit yourself to the overdone offerings of College St. St. Clair is superior if you are looking for authenticity. If what you are after is simply a terrific bowl of pasta than One of A Kind can't be beat. There food is consistently fresh, well balanced and reasonably priced. The service is also great.
There's also a trat on Colborne at Church and King called Spinello's which does a pretty good fresh pasta and their pizza's not too bad either.