I have eaten at most of the restaurants of Baltimore's Little Italy in my quest for satisfying food, and have met with many nights of soggy calamari, and over-priced menus. However, a beacon of hope still shines.
Amicci's is located at 231 South High Street. This is not only one of the cheapest Italian restaurants in the area, but also, in my mind, the best. The food is generally filling (plan on taking some home with you) and hearty, but still light and enjoyable.
The tomato and mottzerella appetizer features rich, delicious mozzarella cheese, the calamari (plan on sharing this with someone as it is huge) comes light, crisp, with minimal breading and an excellent marinara sauce.
Main courses of note include the eggplant Parmesan, made with silky eggplant, crusty breading and lots of cheese, the pasta amicci, pasta with peppers, mushroom, Italian sausage, and other interesting bits, and the gnocchi, which is light and airy in a pleasant pesto or cheesy marinara sauce. Be prepared to wait a bit for a table.