I posed this same type of request for suggestions on the Los Angeles board a few months back and got some great feedback. My husband and I will be in SF for only one night (a Monday night) and are hoping to make the most of it. It would be great to hang out in a neighborhood that has several great restaurants all within walking distance of one another so that we could try a dish or two at each place. We love ethnic cuisines, but are open to anything really good with a nice upscale atmosphere (but not pretentious) that would also allow us to casually drop in without doing a whole formal dinner. A nice eat-at-the-bar type of place would work well. We are not into touristy places, but atmosphere is important and we're not looking for hole-in-the-walls during this visit.
We'll probably be staying in the financial district but are open to driving to other areas within the city.
Any and all suggestions are greatly appreciated!