Since Austin Hounds have done the best burger thing a couple times I though I would throw Houston's Best out there.
Langford's Grocery on Denis in the 4th Ward Montrose area. Lanford's has a perfectly non cemitrical look to the patty. That's right a hand formed monster with tons of grease. Tons of mayo and a huge slice of tomato. If you go on a wednesday and have never been here you might need to get a great beef enchilada served with frijoles al a charro and mex rice. Both sides are as good as I have ever had.
Rudyard's on Waugh in the Montrose area. Rudz serves a nice thick chargrilled burger with a good bun. Make sure to get it cooked medium at the most(I guess this goes without saying).
KC's bar and grill on Fountanview in the Galleria/Richmond Strip area. I was extremely surprised by the quality of burger I got here. Nice juicy burger with good enough fries.
The Palm Steakhouse does a great burger at lunch for $10. It is supposedly ground prime meat and is probably over a pound when all is sadi and done.
Adrians in the 5th ward serves the biggest tastiest damn burger around. This place is off the beaten path but worth searching for. It is in a very rough area but the owner is super friendly and the clientele is always fun.
Good but not great burgers:
Roznofski's has a good burger if you do the double meat.
Bellare Broiler is good for a chili burger.
Goode Co when someone you are dinning with doesn't want a burger.
The Tavern on Gray served one of the best burgers I had ever had then dissapointed on the next 2 visits. I think they put either msg or superfine salt because the meat is salty but you really can't see it (that doesn't make sense).
Tookies in sea brook/kemah area. tookies is good but I think it is a little overrated. I like the 99?
What are some other favorites out there?