I just found your invaluable site and noticed several inquiries on where to eat when driving thru PA on 80. There are a lot of good choices along Route 15, which crosses 80 at Milton, PA. (about 200 miles from NYC):
Go 5 miles south on Rte 15 toward Lewisburg (home of Bucknell Univ.) to the Country Cupboard for some homestyle Central Pa cooking. It may look kind of kitchsy, but the food and prices are great. This is where you take Grandma after church: ham loaf with mac-n-cheese, chicken pot pie(the amish kind not the Swanson kind), pot roast, meatloaf, etc. plus a large buffet at every meal and everything under $10. There is a whole complex including on-site bakery (where we get our Thanksgiving pies), gift shop and greenhouse where you can walk off the meal. Across the road is a local flea/farm/antique market to wander around in also. Here's the website: www.countrycupboardinc.com
If you want to go more upscale, continue on into Lewisburg for Elizabeth's Bistro, Victorian Lady, Gabriel's, Rusty's or Lewisburg Hotel. Here's a site with plenty of info and links to most of these places: www.visitcentralpa.org
Or, go north about 15 miles to Williamsport (home of Little League Baseball) for a bunch of down home Italian places, some with their own 'homemades'(hand-made pasta): Francos(www.francoslounge.com), DiSalvos(www.disalvopasta.com), Mulberry Street Cafe, Triangle, Villa, Tag's, and New Columbia are all great in their own ways. Try the Bullfrog Brewery, Herdic House, Old Corner Hotel for more eclectic stuff. Le Jeune Chef, run by the Penn State culinary arts school (www.pct.edu/lejeunechef)is a worthwhile experience - check out their winelist. Here are two good sites for Williamsport info with links to some of the restaurants: pavisnet.com/lycoming or www.williamsport.org/visitors
Hope this is enough - after all, you "daresn't" go hungry for 400 miles across Pennsylvania!