We just spent 4 days in Prague, and went prepared for good but not great meals. In general, the food was above our expectations. We had a very good lunch at Hergetova Cihelna, just below the Charles Bridge, sitting outside overlooking the river. The tuna tempura style on wasabi mashed potatoes was delicious, as was the arugula and spinach salad with parmesan. My wife had an interesting paella, that was well-prepared. One of our friends had the chicken tika masalla, that was also perfectly cooked. As you can tell from the variety, it's a pretty interesting menu if you are not looking for a heavy czech meal.
But the greatest surprise was our dinner at a new restaurant in Prague named "La Degustation Boheme Borgeoise." It was truly one of the best meals we've ever eaten in Europe! Warning: be prepared for a long (beautifully paced) evening and lots of food.
The chef was trained in Barcelona and studied at CIA--and is attempting to bring a unique dining experience to Prague. Think French Laundry. Based on our experience, he's succeeding, and deserves to be "discovered."
The menu offers three different 10 to 12 course meals, with a couple of amuse bouche thrown in for good measure. There's a traditional menu, a modern central Eurapean menu, and a creative "Borgoise" menu. My wife and I both had the "Borgoise." The menu changes every night, so I'll hit some highlights, with no idea whether any of these things will be on the menu when others visit. Additionally, there's a corresponding wine pairing for each menu, which we also ordered.
Our menu featured a couple of different kobe-style beef preparations, including a tartare, that were outstanding. The duck was fantastic-- a unique combination of flavors that reminded us of a great meal a few years ago at Jean-George in New York. A souffle style fois-gras melted on your tongue. And there was a boullabaisse with the most flavorful broth we've ever tasted.
While it wasn't cheap (by any means), it was very fairly priced, especially considering the weak state of the dollar. At around $100 pp (the menu we ordered was the most expensive of the three), it was an unbelievable evening of food as art and entertainment. ($200 including wine and tip).
If you are going to be in Prague, and want a uniquely delicious dining experience, I highly recommend this.