I think we should keep track of this and what opens in their place.
Here are some closed restaurants so far:
Cafe Cerise (although it closed before the economic dip)
Crudo - Little Italy
Little Italy Bar and Grille
Tesara - Gaslamp
Bully's La Jolla
Turf Club (although I think it moved)
There are many more I am forgetting.
Please add to thread any I am missing, and what is going to open in its place.