We hit New Orleans as part of a five-couple trip recently. A short review:
Mandina's - we drove instead of taking the streetcar up Canal because it was raining, but this was a great Sunday night destination. They have a few extra dishes on Sundays, and they were extremely helpful in making sure we got to try everything. I recommend staying with the basics here (some of the fancier dishes we tried missed by just a little bit).
Commander's Palace - best lunch in America + twenty-five cent martinis. Our waitress even offered to help plan the remainder of our restaurants for us. Turtle soup and redfish of the day. Unbeatable.
Acme Oyster House - I know this place takes some shots as being too touristy, but in my experience they consistently have the best oysters available. You can ask them for a tag and a map and they'll show you where the oysters were swimming that morning. Best seat in the place is at the bar (and you can walk right up to it without waiting in the line).
Palace Cafe - this is the first restaurant I've been to in New Orleans in a long time that I will never, never give another chance. Food was cold, servers were colder and the whole environment was a sad way to end what to that point had been a very celebratory trip. I was born in New Orleans, and wanted to give some friends a feel for the city. This place let me down big time.
Hope that helps someone!