Thanks all for the last minute advice.
We were lucky to have dinner Fri. night at Al Di La. Although I had waited to long to make reservations, they were very friendly, and found us a table in the wine bar after a very short wait. The foccacia was great, we had a delicious arugula/beat/goat cheese salad. Trying to carb up, I ordered two small plates of pasta. The gnocci w/ shrimp was really fantastic, even the small was too much to eat, the gnocci was luscious, but the shrimp...perfectly fresh and perfectly cooked, they were the star rather than an afterthought. Next, the fettucini bolognese which was also great. Only the wines were unremarkable.
After the run, we had cupcakes at Cupcake on King...which had turned my head even as I suffered my way through the last mile. They were very good, I wish someone would pay me $2.75 per cupcake, I'd make them all day long. Followed that up with grilled calamari, good bread, and a bottle of Piper Sonoma Blanc de Noir at Sermet's corner. Bubbles are always pleasant, but if I had it to do over, I would have splurged for the Piper Heidsick.
Finally, after all the advice I recieved, my hostess changed her mind once again, and took us out to dinner at her favorite new restaurant, Twizt. I think she must just be in love with one particular dish, because this place is seriously not in the league with other good Charleston restaurants. The menu is completely disjointed, our waitress was both clueless(mispronounced everything) AND inattentive. Our tuna tartare app was pretty good, but the cod entree was disappointing. The cod itself was fresh and cooked perfectly, but the accompanying "broth" and veggies were bland and didn't seem to complement the dish at all.
So, we drove downtown for a piece of Coconut Cake at Penninsula Grill, which was a madhouse of people with reservations waiting for their tables. Many well-to-do drunk people hanging out at the bar. The cake is delicious, but not as good as mine!
Thanks everyone for your advice, I hope I finally get to try some of your suggestions when I am back in August.