Locke Street in Hamilton is becoming a pretty decent destination to spend some quality time. Brux House is fairly new (at least to me) and is redefining the gastro pub genre with some innovative, interesting, and pretty tasty offerings. They have one of the better bottle/draught lists around, decent looking wine list, and food that comes from the minds behind Quatrefoil (they are termed 'sister restaurants').
I want to go back and try a few more things before I get into the details, but I think many of the fans of Quatrefoil on this board might want to put this on their radar screens. We enjoyed the first outing, and the really enthusiastic and professional staff.