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Pisco is a grape-based brandy from Peru, but it's been imported to San Francisco since the 1830s. Duncan Nicol, owner of the Bank Exchange Saloon, paired it with pineapple, lime juice, sugar, distilled water, and gum arabic to make the now infamous fruity cocktail. However, he never shared his exact recipe with patrons. Some suspect it may have contained cocaine which was still legal at the time. Get the recipe.