I gotta say, my new favorite bar in the Portland is Victory on SE Hawthorne. It's been around a while but it's managed to build a nice little following by word of mouth. It's been rated as one of the best places to have a beer in America by Imbibe Magazine, which has to be based on its selection of Belgian brews.
The food there is also quite excellent, and while I wouldn't exactly call it "destination" eats, I'm pretty much always satisfied, especially with the excellent venison burger.
While the beer list is impressive by my account, I'm actually most comfortable with their cocktails. Their bar is well stocked with good booze, and my favorite cocktail on the list is the tongue-in-cheek Corpse Reviver #4, a riff off of the classic Prohibition-era drink that uses Fernet instead.
Pics and more here:
3652 SE Division St, Portland, OR