I'm surprised there hasn't been more about E66 on Chowhound. I'd been hearing about it for months from friends and locals in the area and finally got the chance to stop by there before a couple rounds of bowling down the street.
First off, it's a brewery, and you can see the tanks behind the counter as you walk in. Cool. They have about 5 -6 regular drafts on the menu plus a few more rotating brews. They do a really good job with all of them. With my group we got to try their Golden Ale, East Bay IPA, Choco-Nut, Red Ale. My favorite was the Choco-Nut, which my friend described as "a light Guinness on a Hawaiian vacation".
There were also a couple of other local beers available on the menu as well.
On to the food, which included a few of what you'd expect at at pub, like fish and chips and a burger, but this place is definitely aiming higher. There was also grilled calamari, seared scallops, porkbelly, chicken cassoulet, risotto and did I mention the burger was Waygu? The food was definitely better than expected.
This spot is a really great addition to the area and makes a perfect stop before or after a movie at the El Cerrito Theater next door.