I hope this question is not too general. I am a Toronto Chowhound visiting SF with two of my old college roommates. We are 1 PhD student, 1 Indie band bassist, and 1 Vancouverite Video Game designer. We are visiting San Francisco from the 23-28th of June. We are staying at one of the HI downtown hostels--but which one escapes me. We are willing to travel and may have a car. Long trips on public transit/cab are no sacrifice for important eating.
My favourite restaurants are places like Lupa and Momofuku in NYC, Cochon in New Orleans, APDC in Montreal, and St. John in London. Places where you can eat well, eat large quantities of strange meats/raw seafood and not feel like it would be an inappropriate place to have dozens of cocktails and tell dumb stories about your undergrad days (St. John might not quite fit the bill on that one I know). I feel like we will mostly be interested in stuffing our faces at modest expense (I will do research on Mexican and burritos for that--we might eat some vietnamese, or chinese, but our home cities do those pretty well.) But I think we have budget room for a couple dinners where we spend about $75 each on food (considerably more if we drink a great deal) and where we will not have to dress in anything particular and where they might play Zeppelin IV but where local, seasonal, homemade-y (and meat-y) things are on offer.
I've searched "Momofuku" and "Manly" on the board, and am conscious of the fact that this does not exactly constitute due diligence in the "making sure your question is not asked every day" department. My apologies if that is the case.